By Roger J. Laham, Donald S. Baim
An interdisciplinary panel of pioneers and opinion leaders evaluation the elemental, preclinical, medical, and developmental pathways to new therapy ideas, reminiscent of healing angiogenesis and myogenesis. The authors reap the benefits of new organic realizing, novel healing goals, a number of on hand and well-studied healing options, and the mandatory imaging suggestions to degree results. Their in-depth discussions disguise the identity of recent healing pursuits and pathways, the research of transcriptional elements, grasp change molecules, cell-based methods, chemokines, a greater figuring out of the results of getting older, endothelial disorder, and hypercholesterolemia according to angiogenic stimuli. Highlights contain exam of drug supply difficulties, results degree, stem remedy, high-risk interventions, improvement pathways, and destiny chances.
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Extra info for Angiogenesis and Direct Myocardial Revascularization (Contemporary Cardiology)
Inhibition of angiogenesis on the chicken chorioallantoic membrane by Ets 1 antisense oligodeoxyribonucleotides]. Verh Dtsch Ges Pathol 1999;83:212–215. 6. Visvader JE, Fujiwara Y, Orkin SH. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev 1998;12:473–479. 7. Hart A, Melet F, Grossfeld P, et al. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity 2000;13:167–177.
Morphological studies of coronary vessels in different species have shown that while rats, rabbits, and pigs have anatomical end arteries with no arteriolar connections, dogs and cats are well endowed with these vessels and guinea pigs hearts exhibit a truly abundant arteriolar network (2). The normal human heart has fewer interconnecting arterioles than a dog heart (3,4). Pigs have a very limited innate collateral circulation, with only sparse endocardial connections; however, dogs have numerous, generally epicardial, innate anastomoses, which are thought to have greater potential for development than those of pigs (5).
CLINICAL IMPLICATIONS The identification of the genomic regulatory regions and the specific transcription factors required for vascular-specific gene expression has several implications regarding the potential treatment of several diseases. First, the identification of vascular-specific fragments allows the possibility of delivering genes and their protein products specifically to blood vessels. The Tie1 promoter has been used not only to direct the expression of the β-galactosidase gene in an endothelial-specific fashion but has also been used to express growth hormone (55).