By Ronald Wetzel, Indu Kheterpal
The power of polypeptides to shape on the other hand folded, polymeric constructions equivalent to amyloids and similar aggregates is being more and more well-known as an immense new frontier in protein examine. This new quantity of Methods in Enzymology in addition to half B (volume 412) on Amyloid, Prions and different Protein Aggregates proceed within the culture of the 1st quantity (309) in containing targeted protocols and methodological insights, supplied through leaders within the box, into the most recent equipment for investigating the constructions, mechanisms of formation, and organic actions of this significant type of protein assemblies.
- Presents exact protocols
- Includes troubleshooting tips
- Provides assurance on structural biology, computational equipment, and biology
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Extra info for Amyloid Prions and Other Protein Aggregates
METHODS IN ENZYMOLOGY, VOL. 413 Copyright 2006, Elsevier Inc. All rights reserved. , 2001) strongly support a role for protein misfolding in the pathogenesis of polyglutamine disorders. , 2004b; Ellisdon and Bottomley, 2004; Horwich, 2002; Stefani and Dobson, 2003), the exact mechanisms of such events as pertains to polyglutamine proteins remain largely unclear. Until relatively recently, in vitro analysis of polyglutamine proteins has been relatively scarce, with the bulk of the research being performed at a cellular level.
Numerical Computer Methods (Part D) Edited by LUDWIG BRAND AND MICHAEL L. JOHNSON VOLUME 384. Numerical Computer Methods (Part E) Edited by LUDWIG BRAND AND MICHAEL L. JOHNSON VOLUME 385. Imaging in Biological Research (Part A) Edited by P. MICHAEL CONN VOLUME 386. Imaging in Biological Research (Part B) Edited by P. MICHAEL CONN VOLUME 387. Liposomes (Part D) Edited by NEJAT DU¨ZGU¨NES, VOLUME 388. Protein Engineering Edited by DAN E. ROBERTSON AND JOSEPH P. NOEL VOLUME 389. Regulators of G-Protein Signaling (Part A) Edited by DAVID P.
Malinchik, S. , Szumowski, K. , and Kirschner, D. A. (1998). Structural analysis of Alzheimer’s beta(1‐40) amyloid: Protofilament assembly of tubular fibrils. Biophys. J. 74, 537–545. , Harricane, M. , and Lange, R. (2003). Structural instability and fibrillar aggregation of non‐expanded human ataxin‐3 revealed under high pressure and temperature. J. Biol. Chem. 278, 31554–31563. Margolis, R. , and Ross, C. A. (2001). Expansion explosion: New clues to the pathogenesis of repeat expansion neurodegenerative diseases.