By Philippe Jeanteur
Splicing of basic RNA transcript is a quasi-systematic step of gene expression in larger organisms. this is often the 1st ebook to spotlight the scientific implications, i.e. ailments, brought on by substitute splicing. replacement splicing not just tremendously raises protein variety but additionally deals quite a few possibilities for aberrant splicing occasions with pathological outcomes. The booklet additionally outlines attainable objectives for remedy.
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Extra info for Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology)
Furthermore, numerous external stimuli have been identified that change alternative splicing patterns. In most cases, these changes are reversible, indicating that they are part of a normal physiological response (Stamm 2002). 30 Tatyana Novoyatleva et al. 2 Human Diseases Caused by Mutation in Splicing Signals Since alternative splicing plays such an important role in gene expression, it is not surprising that an increasing number of diseases are caused by abnormal splicing patterns (Stoilov et al.
Nature 415: 436–442 24 Laurent Bracco et al. Robert J, Vekris A, Pourquier P, Bonnet J (2004) Predicting drug response based on gene expression. Crit Rev Oncol Hematol 51: 205–227 Rohrbach S, Muller-Werdan U, Werdan K, Koch S, Gellerich NF, Holtz J (2005) Apoptosis-modulating interaction of the neuregulin/erbB pathway with antracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes. J Mol Cell Cardiol 38: 485–493 Saccomanno CF, Bordonaro M, Chen JS, Nordstrom JL (1992) A faster ribonuclease protection assay.
Recent results show that the alternative splicing of tau exon 10 is significantly altered in sporadic Alzheimer’s disease (Umeda et al. 2004; Glatz et al. 2006). , Wilms’ tumor, breast cancer, melanoma, and prostate cancer (Table 2). Furthermore, EST analysis demonstrates widespread changes of alternative splicing patterns in cancer cells (Xu and Lee 2003) when compared with normal cells. However, these changes have to be interpreted with caution, since they are not always reproducible by RT-PCR analysis (Gupta et al.