By Alton Meister
Ribonuclease P: An Enzyme with a Catalytic RNA Subunit (S. Altman).
legislation of Escherichia coli Glutamine Synthetase (S. Rhee, et al.).
Glucose 6-Phosphatase: innovations of Membrane-Function courting (K. Sukalski & R. Nordlie).
Chiral Phosphorothioates: Stereochemical research of Enzymatic Substitution at Phosphorus (P. Frey).
Serotonin and Peptide Immunoneuromodulators: contemporary Discoveries and New principles (D. Silverman & M. Karnovsky).
The Phosphyglycerate Mutases (L. Fothergill-Gilmore & H. Watson).
Mechanism and law of the Glutamine-Dependent Carbamyl Phosphate Synthetase of Escherichia coli (A. Meister).
Cummulative Index, Vols.
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Additional info for Advances in Enzymology and Related Areas of Molecular Biology, Volume 62
21a. , and Altman, S . , Biochem. 20, 1902 (1981). 22. , Proc. Natl. Acad. Sci. USA 76, 5495 (1979). 23. , Cell 30,627 (1982). 24. , Cell 45, 177 (1986). 25. ,J . Biol. Chem. 263, 2344 (1988). 26. , and Bruening, G . , Proc. Natl. Acad. Sci. USA 83, 8859 (1986). 27. , Nature 323, 349 (1986). RIBONUCLEASE P 35 28. , Nucleic Acids Res. 14, 3627 (1986). 29. , Cell 48, 535 (1987). 30. , Gene 38, 85 (1985). 31. , Proc. Natl. Acad. Sci. USA 82, 5359 (1983). 32. , J . Mol. Biol. 202, 835 (1988). 33. , Ph.
Kaplin, and S. , unpublished experiments)). The problems of the origin of the genetic code still exists, but, in a sense, it need not be solved in order to get evolution started. All this speculation clearly presupposes that what we see in present- RIBONUCLEASE P 33 day systems reflects, in some manner, the properties of RNA over a billion years ago. Should that indeed be the case, the richness of biochemical mechanisms exhibited by RNA is impressive and can allow for rather complex systems to develop in the absence of protein and DNA.
Analysis of peptides produced from the cyanogen bromide cleavage revealed that the ATP analog labeled Lys47. This Lys is situated in a loop containing Trp-57, and this loop lies across the active site channel from the metal-ion-binding sites (29). However, the side chain of Lys-47 is about 13 8, away from the center of the methionine sulfoximine site (29). It should be pointed out that this loop is quite flexible and that substrate-bindinginduced protein conformational changes may bring this loop closer to the center of the active site since substrate binding, particularly REGULATION OF ESCHERICHIA cOLlGLUTAMINE SYNTHETASE 51 the binding of ATP, causes a large change in tryptophan fluorescence (17).