By Eveline S. Litscher, Paul M. Wassarman
This booklet offers a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical info on hand for the zona pellucida area protein relatives, which impression pathologies similar to infertility, deafness, and melanoma. moreover it:
- Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
- Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
- Speculates as to the evolution of the ZP area and capability therapeutics for ailments stemming from ZP area mutations
- Addresses mammalian and non-mammalian systems
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Additional info for A Guide to Zona Pellucida Domain Proteins
MZP3 vs. 1). ZPD proteins that have diverse functions are found in every major animal group and in a wide variety of tissues and organs. 2 Evolutionary scheme of the organization of ZP genes in mammals, fish, amphibians, reptiles, and birds. ZP1–4 are found in mammals and other vertebrates, ZPd in amphibians and birds, and ZPax in fish, amphibians, and birds. , comparable locations are referred to as synteny). In addition, several ZP pseudogenes have been identified in mammals, for example, a ZP4 pseudogene in mice and ZP1 pseudogene in dogs and cows.
1 mwrrffgvrl tgapkgtcps pqlpwlfclv alvtsavvgn fsttsfpgtv tcyddemkig 61 fpedlgnksw qayvvdsfgn eifrcahvvt senlilraty kscaervhgt yrvnlkflpn 121 ettsnqvvty qvscpaiqad evlgemlaat nctkdfmsvs fsqilpsfdd etmgrepqva 181 wtvivgyspr mqtltlqeam qqgysfvien skiilrvsfn aagvlhyeqe nnhlytvalq 241 ltygppeqrl tlssrmvcil gpvtcnsthm tliipefpga ltaisienrn vpvnlsktsg 301 vavesrngsr lhfnkrilks kmsesgagvq fylpslklrf qyygevvsvi iypefcespv 361 svvaggtCts dgfmdfevys hqtkpalnld tlqvrdtaCq pafknpsqdm vrfhiplngC 421 gtrakfeggq aiyeneihal wadlppnkit rdsefsltvr Cyysgtdlmv rtnisspppp 481 ivsvkpgpls lvlqiypdes ylqpyrddqy pivrylrqpi ymevqvvnrn dpniklvldd 541 Cwatlsvdpm slprwnvivd gCdytldnyr tkfhhvgssv nypnhyqrfe vttfafvsgg 601 qalssliyfh CsvllCdqfh pdsplCsvtC pgssrtkrdi ieekstiasl pgpvflvsdq 661 apsfrgrtnt egpwyegtsi alqvgsilia eiffvavlcl vkcmpgrtra vs ZP3: The polypeptide of ZP3 consists of 422 aa residues and has an SS (aa 1–22; highlighted), a ZPD (aa 49–306; highlighted) with 8 Cys (aa 50, 82, 103, 144, 221, 243, 287, 305; capitalized and underlined), followed by a CFCS (aa 338–341, SRKR; PLACENTAL MAMMALS 25 highlighted and underlined) and a TMD (aa 389–411; highlighted).
2 for the aa sequence and domain organization of mZP1. mZP2: The polypeptide of mZP2 consists of 713 aa residues and has an SS (aa 1–34), a ZPD (aa 364–628) with 10 Cys residues, followed by a CFCS (aa 632–635, RSKR) and a TMD (aa 684–703). 2 for the aa sequence and domain organization of mZP2. mZP3: The polypeptide of mZP3 consists of 424 aa residues and has an SS (aa 1–22), a ZPD (aa 45–302) with eight Cys residues, followed by a CFCS (aa 350–353, RNRR), and a TMD (aa 387–409). 2 for the aa sequence and domain organization of mZP3.